W. Bloemink, De Waag in Deventer. 475 jaar geschiedenis

Geschiedenis van de rekenkunst - van kerfstok tot computer

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mammalian CNS, the actions of which are regulated by ionotropic glutamate (iGlu) and metabotropic glutamate receptors (mGlu). mGlu receptors are a family of G-protein-coupled receptors comprising eight members, refered to as mGlu1-8. Group I receptors include mGlu1 and mGlu5, which when expressed are coupled via Gq to phospholipase C. Group II (mGlu2 and mGlu3) and group III (mGlu4,6,7,8) recep...

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Positive allosteric modulators (PAMs) of a7 nicotinic acetylcholine receptors can enhance ion channel currents and downstream effects of a7 stimulation. We investigated the approach of using noncompetitive antagonists to regulate a7 receptor function, potentially distinguishing effects requiring ion channel currents from signaling induced by nonconducting states. Three small readily reversible ...

`De bevordering en volmaking der proefondervindelijke wijsbegeerte': de rol van het Bataafsch Genootschap te Rotterdam in de geschiedenis van de natuurwetenschappen, geneeskunde en techniek (1769–1988)

For all the obvious hazards and problems of using such a compilation, it is an extraordinary resource. It should surely provide the basis for a much-needed prosopography of the medical trade in the pre-reform era. The sheer proliferation ofnumbers (there are clearly well over 35,000 medical practitioners, in the narrow sense, listed here) provides ample confirmation of the arguments, recently a...

Dmd048561 475..479

This study was designed to evaluate the in vivo activity of cytochrome P450 3A (CYP3A) in 49 healthy Japanese subjects aged 22–58 years using endogenous cortisol 6b-hydroxylation clearance [CLm(6b)], a novel biomarker for CYP3A phenotyping. CLm(6b) in the 49 healthy subjects was 2.40 6 0.79 ml/min with an approximately 4fold interindividual variability of CYP3A activity. The mean clearance in t...